GenEdit Announces Series A Financing and Provides Research Update at TIDES 2021

  • Funding will advance development of NanoGalaxyTM, the company’s proprietary platform of polymer nanoparticles optimized for tissue-selective delivery of genetic medicines, and selection of therapeutic candidates for clinical development by GenEdit
  • Data presented today show GenEdit’s polymer nanoparticles can be optimized for tissue-selective delivery of a range of genetic medicine modalities and dosed multiple times without diminished function of the genetic payload in animal models

SOUTH SAN FRANCISCO, Calif., September 23, 2021 – GenEdit, Inc., a biotechnology company with a mission to develop curative therapies through targeted in vivo delivery of genetic medicines, today announced that it has closed a $26 million Series A financing. New investors Eli Lilly, KTB Network, Ltd., Company K Partners, Korea Investment Partners, DAYLI Partners, KB Investment, IMM Investment, and TIMEFOLIO Asset Management, join existing investors DCVC Bio, SK Holdings, Bow Capital, and Sequoia Capital, participating in the financing. The funding will support the further development of GenEdit’s NanoGalaxyTM platform of non-viral, non-lipid polymer nanoparticles, and the selection for clinical development of therapeutic candidates targeting diseases of the nervous system.

In addition, GenEdit today disclosed new in vivo data demonstrating tissue-selective delivery after intravenous or intrathecal administration of its polymer nanoparticles. This selectivity was achieved through optimization of polymer structure utilizing the NanoGalaxy platform. Additional data show GenEdit’s polymer nanoparticles can be dosed multiple times with functional activity of the payload maintained in each subsequent dose. GenEdit’s CEO and Cofounder Kunwoo Lee, Ph.D. will present this data at 2:30 pm ET today at TIDES 2021 in Room 204AB in a talk entitled, “Delivery of Genetic Medicines with Non-Viral Polymer Nanoparticles.”

“With this financing, we are exploring the universe of opportunities within GenEdit’s NanoGalaxy platform to treat serious diseases without effective treatment options,” said Dr. Lee. “The data presented today indicates we can overcome the historic challenges in the field of gene therapy and establishes the feasibility of using GenEdit’s polymer nanoparticles to deliver genetic medicines to a variety of tissues, including the CNS, with the potential for delivering a therapeutic effect.”

GenEdit’s NanoGalaxy platform includes thousands of chemically distinct polymers, each with unique properties making them amenable to targeting different tissues and cell types and carrying diverse genetic medicine payloads. GenEdit’s polymer nanoparticles can deliver DNA, RNA, or CRISPR ribonucleoprotein, depending on the requirement to add, delete, edit, or silence a gene for therapeutic effect.

“With its NanoGalaxy platform, the GenEdit team has achieved impressive delivery to cells of the central nervous system and has a tunable platform to target genetic medicines to different tissue types,” said Andrew Adams, Vice President of New Therapeutic Modalities at Eli Lilly and GenEdit Board observer. “Solving the delivery problem is what will truly launch genetic medicines to being an essential therapeutic modality for a wide range of diseases.”

 

About GenEdit, Inc.

At GenEdit, our mission is to develop curative therapies through targeted in vivo delivery of genetic medicines. Our NanoGalaxy™ platform of non-viral, non-lipid polymer nanoparticles will enable a universe of opportunities to launch the next generation of safe and effective genetic medicines. To bring these medicines to patients, we are developing our own internal pipeline and delivering a wide variety of therapeutic payloads for our partners’ programs. For more info, visit www.genedit.com.

 

Contacts

Company Contact: Kunwoo Lee, Ph.D., GenEdit, Inc., info@genedit.com, +1 (510) 766-2575

Media Contact: Jessica Yingling, Ph.D., Little Dog Communications Inc., jessica@litldog.com, +1 (858) 344-8091

 

GenEdit Expands Leadership Team to Advance Targeted Genetic Medicines into Clinical Trials

SOUTH SAN FRANCISCO, Calif., September 22, 2021 – GenEdit, Inc., a biotechnology company with a mission to develop curative therapies through targeted in vivo delivery of genetic medicines, today announced that it has added two accomplished industry executives to its leadership team. The company has appointed Romuald Corbau, Ph.D., as Chief Scientific Officer (CSO) and Aaron Mishel as Chief Financial Officer (CFO).

As part of his 20-plus years of drug discovery and development experience, Dr. Corbau led the translation of innovative genetic medicine therapies into clinical development at Spark Therapeutics and Freeline. Mr. Mishel brings to GenEdit more than twenty years of healthcare sector experience across various leadership positions in finance, operations, corporate development, and investment banking equity research.

“The expansion of the management team comes at a pivotal time for GenEdit as we further develop our NanoGalaxyTM platform to enable genetic medicine delivery and select therapeutic candidates for clinical development,” said Kunwoo Lee, Ph.D., GenEdit’s CEO and Co-founder. “Romu and Aaron bring a depth of experience and expertise that will be invaluable as we build our company, platform, and pipeline to advance new treatments internally and with partners for a broad range of diseases with unmet medical needs.”

Dr. Corbau joins GenEdit from Freeline, where he led the research organization and built differentiated systemic gene therapy capabilities. Before Freeline, he was the Translational Lead at Spark Therapeutics. At both companies, Dr. Corbau was focused on the discovery and development of AAV-based gene therapies. Prior to that, he was Director of Biology at the Center for Innovation and Stimulation of Drug Discovery. Dr. Corbau began his pharmaceutical career at Pfizer Global Research & Development.

“GenEdit has a truly convincing approach to the delivery of genetic medicines that offers advantages over other vector systems,” added Dr. Corbau. “The team has demonstrated that NanoGalaxy polymer nanoparticles can achieve the delivery of a wide range of payloads to target tissues and can be successfully redosed. I look forward to working with the team to explore all the possibilities within NanoGalaxy to develop innovative therapies that will benefit as many patients as possible.”

Prior to joining GenEdit, Mr. Mishel served as the Chief Financial Officer of Magnetic Insight. Previously, he was the Head of Finance for Modis Therapeutics, where he helped lead the company’s sale to Zogenix. Prior to Modis, he was Director of Business & Corporate Development at BioMarin Pharmaceutical. Mr. Mishel also worked in Equity Research at Deutsche Bank and Thomas Weisel Partners, where he covered the specialty pharmaceuticals industry.

Mr. Mishel concluded, “I am thrilled to be joining GenEdit at this important stage as the company transitions its focus from demonstrating proof-of-concept for the platform to selecting initial therapeutic programs for clinical development. I look forward to working with the GenEdit team to ensure that the company’s platform technology and therapeutic programs realize their full potential.”

 

About GenEdit, Inc.

At GenEdit, our mission is to develop curative therapies through targeted in vivo delivery of genetic medicines. Our NanoGalaxy™ platform of non-viral, non-lipid polymer nanoparticles will enable a universe of opportunities to launch the next generation of safe and effective genetic medicines. To bring these medicines to patients, we are developing our own internal pipeline and delivering a wide variety of therapeutic payloads for our partners’ programs. For more info, visit www.genedit.com.

 

Contacts

Company Contact: Kunwoo Lee, Ph.D., GenEdit, Inc., info@genedit.com, +1 (510) 766-2575

Media Contact: Jessica Yingling, Ph.D., Little Dog Communications Inc., jessica@litldog.com, +1 (858) 344-8091